【摘要】 目的拟通过人群膳食干预试验,从临床角度研究植物雌激素大豆异黄酮对妇女更年期综合征症状及主要并发症骨质疏松的预防治疗作用。方法依据纳入和排除标准,在哈尔滨地区筛选出更年期妇女90人,随机双盲法分为大豆异黄酮剂量组和安慰剂对照组,每人每天服用大豆异黄酮90mg或者安慰剂,试验期限6个月。通过调查问卷形式记录Kupperman评分,评价更年期综合征症状改善情况;生化学方法检测试食对象血清中骨代谢指标血清钙、血清磷和血清碱性磷酸酶;超声测定桡骨远端和胫骨中段的骨密度。结果大豆异黄酮组Kupperman评分中12项指标的评分均显著下降,反应骨转换的指标血清碱性磷酸酶显著下降,胫骨骨密度显著增加,均有统计学意义。讨论大豆异黄酮可有效改善妇女更年期综合征症状,增加骨密度,预防和治疗由于更年期综合征引起的骨质疏松。更多还原

【Abstract】 Objective To study the effect of soy isoflavone on climecteric syndrome and bone mineral density in women.Methods Ninety climecteric women were selected in Harbin and were divided into two groups with doubleblind randimization.All subjects were given isofalvone 90 mg/d or placebo for 6 months.Their menopause symptoms were recorded according to Kupperman Score.Bone metabolism markers were measured by biochemistry methods and the BMD of radius and tibia was measured by ultrasound.Results The Kupperman score and APK in isoflavone group decreased significantly,and the tibia mineral increased significantly compared with the placebo subjects.Conclusions Soy isoflavone ameliorates the climecteric syndrome,increases the BMD,thus to prevent and treat climecteric syndrome and,furthermore,osteoporosis.更多还原