【摘要】 目的评价奥沙利铂(L-OHP)联合氟尿嘧啶(5-Fu)、亚叶酸钙(CF)方案治疗晚期结直肠癌的疗效与毒副反应。方法奥沙利铂130 mg/m2,静滴4 h,第1天;亚叶酸钙200 mg静脉滴注2 h,5-Fu 300 mg/m2,持续静滴6~8 h,第1~5天(亚叶酸钙滴完后用);21 d为1周期,行2周期治疗后评价疗效。结果全组完全缓解(CR)1例,部分缓解(PR)12例,总有效率(CR+PR)为43.3%。毒性反应以骨髓抑制、感觉性神经毒性为主,多为Ⅰ~Ⅱ度,其中白细胞减少发生率为46.7%,感觉性神经毒性发生率为77.7%,无化疗相关死亡。结论奥沙利铂联合氟尿嘧啶、亚叶酸钙治疗晚期结直肠癌疗效肯定,毒副反应能耐受。更多还原

【Abstract】 Objective To study the efficacy and toxicity of oxaliplatin plus fluorouracil and calcium folinate in treatment of advanced colorectal cancer.Methods Oxaliplatin was given at the dose of 130 mg/m~2,iv gtt for 4 hours on day 1,calcium folinate 200 mg/m~2 ivgtt for 2 hours on days 1 to 5,followed by fluorouracil 300 mg/m~2 ivgtt for 4-6 hours on days 1 to 5.The treatment was given every 3 weeks.Results One patient achieved CR and 12 patients achieved PR,with the overall response rate(CR+PR)of 43.3%.The major toxicity included myelosuppression and neurosensory toxicity.Leucopenia was observed in 46.7% of the patients and neuro-sensory toxicity in 77.7%.There was no any death event during treatment.Conclusion This study shows that the regimen of oxaliplatin plus fluorouracil and calcium folinate for treatment of advanced colorectal cancer is effective and tolerable.更多还原