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胃癌患者血清β2-微球蛋白含量变化的临床意义
Clinical significances of changes in serum β2-microglobulin in patients with stomach cancer
【摘要】 目的探讨胃癌患者血清β2微球蛋白(β2-microglobulin,β2-MG)含量变化及临床应用价值。方法用免疫放射分析法(RIA)检测62例胃癌、30例慢性胃炎伴幽门螺杆菌(Helicobacterpylori,HP)感染以及30例正常健康人血清β2MG含量;动态检测胃癌手术前后β2MG含量变化。结果胃癌组血清中β2-MG含量明显高于健康对照组(P<0.05)和慢性胃炎伴HP感染组(P<0.05);胃癌术前血清β2-MG含量增高者,术后含量明显降低(P<0.05);有转移复发时,β2MG含量再度升高。结论检测血清β2MG含量变化在胃癌辅助诊断以及疗效、复发判断方面具有重要临床意义。
【Abstract】 Objective To explore the changes in serum level of β2-microglobulin(β2-MG) and the value of its clinical use in the patients with stomach cancer.Methods The serum levels of β2-MG were measured by RIA in 62 patients with stomach carcinoma,30 patients with chronic gastritis accompanied with Helicobacter pylori(HP) infection and 30 healthy people. The changes in β2-MG serum levels were also measured in operative patients before and afteroperation.Results The level of serum β2-MG in patients with stomach carcinoma was much higher than that in chronic gastritis accompanied with HP infection(P<0.05), and normal control group(P<(0.05)). The high levels of serum β2-MG in preoperative patients with stomach carcinoma were reduced dramatically after operation(P<0.05). On the other hand, the reduced level of postoperative serum β2-MG was raised again when matastasis or recurrence occurred.Conclusion Measuring the level of patients’ serum β2-MG has important significances in assisting diagnosis and judgement of therapeutic effects and relapse for stomach carcinoma.
【Key words】 Stomach neoplasms; β2-microglobulin; Adjutant diagnosis; Relapse;
- 【文献出处】 中国肿瘤临床与康复 ,Chinese Journal of Clinical Oncology and Rehabilitation , 编辑部邮箱 ,2005年01期
- 【分类号】R735.2
- 【被引频次】7
- 【下载频次】64