【摘要】 目的探讨胃癌患者血清β2微球蛋白(β2-microglobulin,β2-MG)含量变化及临床应用价值。方法用免疫放射分析法(RIA)检测62例胃癌、30例慢性胃炎伴幽门螺杆菌(Helicobacterpylori,HP)感染以及30例正常健康人血清β2MG含量;动态检测胃癌手术前后β2MG含量变化。结果胃癌组血清中β2-MG含量明显高于健康对照组(P<0.05)和慢性胃炎伴HP感染组(P<0.05);胃癌术前血清β2-MG含量增高者,术后含量明显降低(P<0.05);有转移复发时,β2MG含量再度升高。结论检测血清β2MG含量变化在胃癌辅助诊断以及疗效、复发判断方面具有重要临床意义。更多还原

【Abstract】 Objective To explore the changes in serum level of β₂-microglobulin（β₂-MG） and the value of its clinical use in the patients with stomach cancer.Methods The serum levels of β₂-MG were measured by RIA in 62 patients with stomach carcinoma,30 patients with chronic gastritis accompanied with Helicobacter pylori（HP） infection and 30 healthy people. The changes in β₂-MG serum levels were also measured in operative patients before and afteroperation.Results The level of serum β₂-MG in patients with stomach carcinoma was much higher than that in chronic gastritis accompanied with HP infection（P<0.05）, and normal control group（P<（0.05））. The high levels of serum β₂-MG in preoperative patients with stomach carcinoma were reduced dramatically after operation（P<0.05）. On the other hand, the reduced level of postoperative serum β₂-MG was raised again when matastasis or recurrence occurred.Conclusion Measuring the level of patients’ serum β₂-MG has important significances in assisting diagnosis and judgement of therapeutic effects and relapse for stomach carcinoma.更多还原