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哌醋甲酯抗过敏性休克的实验研究

Experimental study on antiallergic shock of ritalin

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【作者】 郑海洪闫晓辉谷春山谷欣孟令云齐晓凤

【Author】 ZHENG Hai-hong~1,YAN Xiao-hui~2,GU Chun-shan~3,GU Xin~4,MENG Ling-yun~2,QI Xiao-feng~1( 1.The Second Hospital of Harbin Medical University LAC,Heilongjiang Harbin 150086,China;2. Department of pathology,Harbin Staffs Medical College,Heilongjiang Harbin 150080,China;3.Harbin University of Commerce,Heilongjiang Harbin 150076,China )

【机构】 哈尔滨医科大学附属第二医院动物实验中心哈尔滨市职工医学院哈尔滨商业大学哈尔滨医科大学哈尔滨医科大学 黑龙江哈尔滨150086黑龙江哈尔滨150080黑龙江哈尔滨150076毕业生毕业生

【摘要】 目的:观察哌醋甲酯抗过敏性休克的作用,为临床用药提供依据。方法:选用豚鼠和Wistar大鼠,分别以马血清(DES)和鸡蛋蛋白(OVA)制备过敏性休克模型,设模型组,盐酸肾上腺素(Adr)阳性对照组及哌醋甲酯0.5,1,2mg·kg-1体重3个剂量组,观察各组死亡率并作χ2检验。结果:在豚鼠实验中,模型组、Adr及哌醋甲酯3个剂量组死亡率分别为11/12;3/12;7/12;4/12;3/12。在哌醋甲酯3组中除小剂量外,其余两组死亡率与模型组相比,P<0.05,与Adr组相比,P>0.05。在大鼠实验中结果类似豚鼠实验,哌醋甲酯中、大剂量组死亡率与模型组比较,P<0.05,与Adr组比较,P>0.05。结论:两项实验均表明哌醋甲酯有抗过敏性休克作用。

【Abstract】 OBJECTIVE To observe the effect of ritalin on allergic shock and provide the basis for clinical use of the drug.METHODS Guinea pigs and Wistar rats were given to DES and OVA,respectively for causing allergic shock models,at the same time,the animals were divided into the control groups (model animals),the positive control group of Adr,three doses groups of ritalin 0.5 mg·kg~-1; of ritalin 1 mg·kg~-1; of ritalin 2 mg·kg~-1 to observe the mortality rate of every group and makeχ~2 test.RESULTS In the experiment with guinea pigs,the mortality rate of the model,Adr and ritalin three doses groups were 11/12; 3/12; 7/12; 4/12 and 3/12,respectively. In the ritalin three dose groups,except minimal dose group,the mortality rate of other two groups was less (P<0.05),compared with model group. However the mortality rate of ritalin groups had no difference (P>0.05).compared with Adr group. In the experiment with rats,the result of the mortality rate was the same as the experiment with guinea pigs. The mortality rate of maximal and middle dose groups decreased (P<0.05),compared with the model group and no difference (P>0.05),compared with Adr group.CONCLUSION It is demonstrated that ritalin has antiallergic shock effect in animal studies.

【关键词】 哌醋甲酯过敏性休克马血清鸡蛋蛋白
【Key words】 ritalinallergic shockDESOVA
  • 【文献出处】 中国医院药学杂志 ,Chinese Journal of Hospital Pharmacy , 编辑部邮箱 ,2005年07期
  • 【分类号】R965
  • 【下载频次】71
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