【摘要】 目的探讨人参炔醇对神经细胞的营养及保护作用。方法通过PC12细胞、新生鼠脊髓背根神经节研究人参炔醇的神经营养和保护作用。结果人参炔醇可时间、剂量依赖性地促进PC12细胞轴索生长,促进细胞分化标志物MAP-2B表达; 8 μmol·L-1的人参炔醇可与5 μg·L-1的神经生长因子协同促进大鼠脊髓背根神经轴索的延长;对叠氮钠致PC12细胞损伤有剂量依赖性保护作用。结论人参炔醇对PC12细胞具有类似神经生长因子的神经营养和神经保护作用。更多还原

【Abstract】 OBJECTIVE To investigate the neurotrophic and neuroprotective effects of panaxynol on PC12 cells.METHODS The neu-rites of PC12 and dorsal root ganglion of rats were used as screen models to study the neurotrophic and neuroprotective effects of panaxynol. RESULTS Panaxynol time-and dose-dependently promoted the neurite outgrowth and the express of the differentiation marker of PC12 cells; 8 μmol·L-1 panaxynol coordinated with 5 μg·L-1 NGF promoted the neurite outgrowth of DRG; 8 μmol·L-1 panaxynol dose-dependently protected PC12 cells from injury of NaN3. CONCLUSION It indicates that panaxynol has neurotraphic and neuroprotective effects on PC12 cells.更多还原