【摘要】 目的　研制用于结肠靶向的吲哚美辛瓜尔胶压制包衣片。方法　正交设计得吲哚美辛片芯的最佳处方 ,湿法制粒得到瓜尔胶压制包衣用颗粒 ,将两者压片得到压制包衣片 ,并测其体外释放度。结果　体外释药试验表明 ,压制包衣 ,使药物在0 1mol·L-1HCl和pH 7 4磷酸盐缓冲液中不释放 ,在有半乳甘露糖苷酶的pH 6 8磷酸盐缓冲液中能全部释放。结论　瓜尔胶作为压制包衣材料 ,能使药物达到结肠靶向给药效果。更多还原

【Abstract】 OBJECTIVE To prepare indomethacin compression tablets coated with guar gum for colon specific drug delivery METHODS According to disintegration test results,indomethacin core tablets were designed by orthogonal methods and a guar gum/microcrystalline cellulose mixture as the coat layer was used with wet granulation technique The release properties of indomethacin from compression coated tablets were investigated in the physiological environment of stomach and small intestine RESULTS Drug release was influenced while varying the grade of guar gum and the ratio of guar gum and microcrystalline cellulose No drug release was observed in 0 1 mol·L -1 HCl and pH 7 4 phosphate buffer solution(PBS) The coat would erode/degrade with the presence of enzyme (galactomannanase),and drug delivered completely to the colon (pH 6 8 PBS) CONCLUSION The study clearly established that guar gum,in the form of compression coat,is a potential carrier for drug targeting to colon更多还原