【摘要】 目的:探讨低密度脂蛋白受体(LDL-R)基因和载脂蛋白(apo)CⅢ基因多态性与动脉粥样硬化性脑梗死(AC I)的关系。方法:用聚合酶链反应(PCR)技术检测中国辽宁籍汉族健康人104例和AC I患者77的LDL-R基因NcoⅠ、apoC-Ⅲ基因SacⅠ多态性及血脂、脂蛋白含量。结果:对照组N+及S+等位基因频率为0.667、0.274;AC I组为0.662、0.329,差异不显著(P>0.05),但AC I组S-S+与N-N+、N+N+联合存在时的频率为0.45,显著高于对照组(P<0.05),致AC I的发病相对风险率(RR)为4.2(P<0.05),致血清TG、TC、LDL-C升高的RR依次为14.30、9.40、17.40。结论:LDL-R基因N-N+、N+N+、apoC-Ⅲ基因S-S+联合存在与AC I患者血清高TG、高TC、高LDL-C相关,可能是致AC I的遗传易患因子。更多还原

【Abstract】 Objective: To investigate the relationship between polymorphism of low density lipoprotein(LDL) receptor gene NcoⅠ and apoC-Ⅲ gene SacⅠand the atherosclerotic cerebral infarction(ACI).Methods: The PCR method was used to detect the polymorphism of LDL-R gene NcoⅠand apoC-Ⅲ gene SacⅠ,blood lipid,and lipoprotein content in 104 healthy controls and 77 ACI patients.All the subjects were Han nationality in Liaoning province,China.Results: N~+ and S~+ allele gene frequencies of control group and ACI group were 0.667,0.274 and 0.662,0.329,respectively.There was no significant difference between the 2 groups(P>0.05).The combined appearance frequency of S~+ and N~+ allele gene in ACI group was 0.45,which was markedly higher than that of control group(P<0.05).Relative risk(RR) leading to ACI was 4.20(P<0.05);RR leading to the rise of TG,TC,and LDL-C were 14.30,9.40,and 17.40.Conclusion: The combined appearance of N~+ and S~+ allele gene in LDL-R and apoCⅢ gene can affect the blood lipid and lipoprotein content.It may also have close relationship with the occurrence of ACI.更多还原