【摘要】 目的: 了解p16基因蛋白在人肺癌组织中的表达情况。方法: 应用免疫组化SP法检测69例肺癌及癌旁正常肺组织, 21例肺良性疾病肺癌组织中p16基因蛋白的表达。结果: 肺良性疾病及癌周正常肺组织p16蛋白阳性率分别为100%和91. 3%,高于肺癌组织中的39. 1%,差异显著(P<0. 05 );p16蛋白表达与肺癌病理类型、临床分期及淋巴结转移有明显的相关性(P<0. 05);与组织学分级无关。结论: p16基因蛋白的表达情况与肺癌的发生、发展有关。更多还原

【Abstract】 Objective: To investigate the expression of p16 gene protein in lung cancer. Methods: With SP immunohistochemistry, tissue of 21 cases of lung benign diseases and 69 of lung cancer were stained by using the multiclonal antibody against the human p16 protein. Results: Expression of p16 gene protein was observed in 91.3% of normal tissues, while 39.1% of lung cancer tissues showed p16 gene protein expression (P<0.05). The expression of p16 protein was significantly correlated with the pathologic type, clinical stage, and lymph node metastasis (P<0.05). Conclusion: The low expression of p16 protein was related to the carcinogenesis and development of lung cancer.更多还原