【摘要】 目的研究盐酸托莫西汀的合成工艺。方法以1-苯丙醇为起始原料,经氯代、溴代、醚化、胺化、拆分、氯化氢成盐6步反应合成盐酸托莫西汀。结果与结论合成盐酸托莫西汀的总收率为16.4%,比文献值提高了5.4%。改进了中间体5和6的合成工艺。更多还原

【Abstract】 Aim To study the synthesis of atomoxetine hydrochloride.Methods Atomoxetine hydrochloride was synthesized using 3-phenylpropanol as the starting material via six steps,such as chlorination,bromination,etherification,substitution,separation of levorotary isomer and acidification by gaseous hydrogen chloride.Results and conclusions The target compound was synthesized from 3-phenylpropanol,and the overall yield was 16.4%,5.4% higher than the yield reported.The preparation process of the intermediate 5 and 6 was also improved.更多还原