【摘要】 ABC类载体蛋白(ATP binding cassette)家族中的药物转运蛋白影响许多药物的药代动力学过程。P-糖蛋白(P-gp),多药耐药相关蛋白(MRP),乳腺癌耐药蛋白(BCRP)同属于ABC类载体蛋白。转运蛋白基因缺失动物模型是目前对膜转运蛋白作用机制研究的重要手段。各种转运蛋白缺失的大鼠和小鼠模型是研究其所对应缺失的转运蛋白的生理作用以及研究各种药物在组织中的聚集和毒性情况的一种很好的模型。本文综述了转运蛋白基因缺失动物模型在转运蛋白作用机制、转运行为和寻找新的转运蛋白抑制剂方面的应用。更多还原

【Abstract】 Active drug transporters of the ATP binding cassette(ABC)-containing family of proteins have a major impact on the pharmacokinetics of most drugs in use today.P-glycoprotein(P-gp),multidrug resistance-associated protein(MRP),and breast cancer resistance protein(BCRP) are ABC-superfamily of membrane transport proteins(transporters).The transporter gene knockout mouse/rat models have been proven to be a useful tool in the study of the role of transporters in tissue accumulation and toxicity of various organic chemicals.This paper reviewed the applications of the transporter gene knockout mouse/rat models on transporters′mechanism,aiming to search new applications of the transporter inhibitor.更多还原