【摘要】 目的探讨枸杞复合制剂对免疫系统功能的影响。方法以小鼠为动物模型,观察不同剂量(1·67、3·33、10·00ml/kg,体重)枸杞复合制剂对小鼠体重、免疫器官相对重量、细胞免疫功能、体液免疫功能、单核巨噬细胞功能及非特异免疫功能(NK细胞活性)的影响。结果与对照组相比,枸杞复合制剂3个剂量组小鼠DTH反应程度分别增加60%、84%和92%;ConA刺激的脾淋巴细胞增殖能力分别提高了31%、73%和76%;IgM-PFC数目明显增加(每5×106个脾细胞中PFC数目分别为:5145、5840、6455,对照仅为2600);碳粒廓清指数分别增加32%、41%和55%。但本研究中未发现枸杞复合制剂对腹腔巨噬细胞吞噬功能及NK细胞活性的影响。结论枸杞复合制剂具有增强小鼠免疫功能的作用。更多还原

【Abstract】 Objective To observe the effects of Lycium barbarum L.Composita(LBC) on immune functions. Methods Female Kunming(KM) mice(6-8 weeks old,n=160)were administered for 30 days with 1.67,3.33 and 10.00 ml/kg LBC. Spleen and thymus were weighted and cell-mediated immune functions, humoral immune functions,phagocytic functions of mononuclear phagocyte and NK cell activity assays were performed by conventional methods. Results In comparison with control group,1.67,3.33 and 10.00 ml/kg LBC increased the capacity of DTH response by 60%,84% and 92%,while lymphocyte proliferation capacity was also endanced by 31%,73% and 76% respectively.IgM-PFC number increased significantly(5145,5840,6455 vs 2600 per 5×10~6 spleen cells).Also,carbon clearance and HC_ 50 were improved evidently,while no obvious effects on phagocytosis capacity and NK cell activity were observed in our study. Conclusion LBC could improve the immune functions in mice.更多还原