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正交试验优选复方环丙沙星凝胶基质组成及制备工艺

Optimization of Base Material Compositions of Compound Ciprofloxacin Gel by Orthogonal Test and Its Preparation Technology

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【作者】 刘铭佩李芳焦海胜朱恒王爱兰梁晓东

【Author】 LIU Mingpei,LI Fang,JIAO Haisheng,ZHU Heng(Dept.of Pharmacy,No.2Hospital of Lanzhou Univerˉsity,Lanzhou730030,China) WANG Ailan,LIANG Xiaodong(Dept.of Pharmacy,Lanzhou Medical College,Lanzhou730030,China)

【机构】 兰州大学第二医院药剂科兰州医学院药学系兰州医学院药学系 兰州市730030兰州市730030兰州市730030

【摘要】 目的:优选复方环丙沙星凝胶基质组成及制备工艺。方法:选取盐酸环丙沙星、卡波姆-940、甘油、三乙醇胺处方用量4种因素为可变因素,以成品稳定性为考察指标,选用L9(34)表进行正交试验。结果:最优的基质组成及工艺为盐酸环丙沙星0.3%、卡波姆-9401%、甘油7.5%、三乙醇胺2%。结论:按优选工艺制备的凝胶符合《中国药典》2000年版规定。

【Abstract】 OBJECTIVE:To optimize base material compositions and preparation technology for compound ciprofloxacin gel.METHODS:4factors,ciprofloxacin,carbomer-940,glycerine,triethanolamine(in formula dosages)were selected as variable factors,the stability of the preparation was taken as the index for investigation and table L 9 (3 4 )was used to conduct the orthogonal experiment.RESULTS:The optimum base material composition and technology were the following,ciprofloxacin0.3%,carbomer-9401%,glycerine7.5%,triethanolamine2%.CONCLUSION:The compound ciprofloxacin gel prepared based on the optimized technology is in conformity with the specification stated in Chinese Pharmacopoeia(2000).

  • 【分类号】TQ463;
  • 【被引频次】9
  • 【下载频次】191
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