【摘要】 目的:优选复方环丙沙星凝胶基质组成及制备工艺。方法:选取盐酸环丙沙星、卡波姆-940、甘油、三乙醇胺处方用量4种因素为可变因素,以成品稳定性为考察指标,选用L9(34)表进行正交试验。结果:最优的基质组成及工艺为盐酸环丙沙星0.3%、卡波姆-9401%、甘油7.5%、三乙醇胺2%。结论:按优选工艺制备的凝胶符合《中国药典》2000年版规定。更多还原

【Abstract】 OBJECTIVE:To optimize base material compositions and preparation technology for compound ciprofloxacin gel.METHODS:4factors,ciprofloxacin,carbomer-940,glycerine,triethanolamine(in formula dosages)were selected as variable factors,the stability of the preparation was taken as the index for investigation and table L 9 (3 4 )was used to conduct the orthogonal experiment.RESULTS:The optimum base material composition and technology were the following,ciprofloxacin0.3%,carbomer-9401%,glycerine7.5%,triethanolamine2%.CONCLUSION:The compound ciprofloxacin gel prepared based on the optimized technology is in conformity with the specification stated in Chinese Pharmacopoeia(2000).更多还原