【摘要】 相关性分析只能说明两者有否关系,但并不能说明两者之间的因果关系。高Hcy虽被认为是冠心病的危险因素,但流行病学方面尚无反证资料,即给予降低高Hcy水平的治疗可明显减少冠心病的发病率,因此本文如果能在设计上增加给予叶酸等药物治疗后的Hcy与CRP关系的资料,则更有临床意义,这也是本文设计上的缺陷。目的:探讨血浆同型半胱氨酸(Hcy)和C-反应蛋白(CRP)水平的关系。方法:分别采用高压液相色谱的方法和酶联免疫吸附试验方法检测810例研究对象的血浆Hcy(按血浆Hcy水平分为两组,即<15μmol/L组和≥15μmol/L组)和CRP水平,并进行统计学分析。结果:血浆Hcy水平≥15μmoL/L组的平均CRP水平显著高于血浆Hcy<15μmol/L组[(2.40±3.37)mg,/Lvs(1.67±2.67)mg/L,P<0.01];血浆CRP水平>1.38mg/L人群中Hcy≥15μmoL/L者发生率显著升高,有显著性差异(P<0.05)。结论:血浆Hcy和CRP这两种心血管疾病危险因素之间具有相关性。更多还原

【Abstract】 Objective: To investigate the relationship between plasma homocysteine (Hcy) level and C reactive protein (CRP) level. Methods: The plasma levels of Hcy and CRP were detected through high performance liquid chromatography and enzyme linked immunosorbent assay, respectively, and were analysed. Results: The CRP level was significantly increased in the group with high Hcy level( ≥15 μmol/L) compared to the control group(≤15 μmol/L) ( 2. 40±3. 37 mg/L vs 1. 67±2. 67 mg/L,p <0. 01). The incidence rate of hyperhomocysteinemia was significantly increased when the CRP level was beyond 1. 38 mg/L(p <0. 05). Conclusion: The CRP level is associated with the Hcy level.更多还原