【摘要】 目的探讨孕妇血清IL6与胎膜早破及绒毛膜羊膜炎的关系。方法2004年1～10月中山大学附属第三医院对46例胎膜早破孕妇和50例正常孕妇,采用ELISA法测定血清IL6质量浓度,分娩时胎盘胎膜送病理检查。结果胎膜早破孕妇血清IL6质量浓度明显高于对照组,并随破膜时间的延长其含量升高(P<0.05),而且有绒毛膜羊膜炎者血清IL6高于无绒毛膜羊膜炎者及对照组(P<0.01);38例自然临产的胎膜早破孕妇中,血清IL6≥30ng/L者,其取样距临产时间短于血清<30ng/L者(P<0.05)。结论血清IL6含量升高对早期诊断胎膜早破合并绒毛膜羊膜炎及预测分娩具有重要意义。更多还原

【Abstract】 Objective To study the relationship between maternal serum interleukin-6 (IL-6)concentrations in patients with premature rupture of membrane(PROM) and chorioamnionitis. Methods Serum IL-6 concentrations of 46 women with PROM(the study group ) and 50 normal pregnancy(the control group) were measured by ELISA . The placenta and membrane were detected after labor. Chorioamnionitis were diagnosed histopathologically. Results The level of serum IL-6 in the study group was significantly higher than that in the control group(P<0.05); along with the prolong of the interval from collection to PROM, the level of serum IL-6 was significantly increased. In the study group, the level of serum IL-6 in the women with chorioamnionitis was significantly higher than that without chorioamnionitis and that in the control(P<0.01). When the serum IL-6 concentrations was at least 30 ng/L, the median interval from collection to labor was significantly shorter than that at less than 30 ng/L(P<0.05). Conclusion Maternal serum IL-6 level appears to be elevated in women with PROM,which may prove to be a useful marker for detection of chorioamnionitis and predicting delivery.更多还原