【摘要】 目的研究妊娠期高血压疾病患者子宫蜕膜组织中Th1和Th2细胞比率变化,探讨其变化在发病中的作用。方法河北医科大学第二临床医学院于2004年2～9月采集12例正常妊娠孕妇,10例妊娠期高血压和25例子疒间前期患者子宫蜕膜组织,采用流式细胞技术分别检测Th1/Th2细胞比率。结果(1)子疒间前期组和妊娠期高血压组Th1/Th2细胞比率明显高于正常妊娠组(P<0.05)。(2)子疒间前期组Th1/Th2比率明显高于其他两组(P<0.01),妊娠期高血压组明显高于正常妊娠组(P<0.05)。在子疒间前期组,随病情的严重程度的增加,其比率变化呈加重趋势,但与孕周无明显关系。(3)子疒间前期患者Th1/Th2比率与平均动脉压、24h尿蛋白量呈正相关(P均<0.01)。结论Th1/Th2比率变化可能是妊娠期高血压疾病发病的重要原因。更多还原

【Abstract】 Objective To study the changes of T-helper1 and T-helper2 (Th1 and Th2) ratio in the uterine decidua was collected from patients with hypertensive disorder complicating pregnancy and to investigate the function of them in the pathogenesis of hypertensive disorder complicating pregnancy. Methods Uterine decidua was collected from 12 healthy pregnant women,10 patients with gestational hypertension, 25 patients with pre-eclampsia in the Second Hospital of Hebei Medical University from February to September. Th1/Th2 ratio in uterine decidua was determined by flow cytometry. Results (1)The percentage of Th1 cells with pre-eclampsia and gestational hypertension in uterine decidua was much higher than that of healthy pregnancy group (P<0.05).(2)The ratio of Th1/Th2 in uterine decidua with pre-eclampsia was much higher than other groups (P<0.01), and Th1/Th2 ratio with gestational hypertension group was also significantly higher than that of healthy pregnancy group(P<0.05). Among the patients with pre-eclampsia,with the development of the disease,the ratio of Th1/Th2 intended to increase. But it seemed to have no correlation with gestational weeks.(3)Ratio of Th1/Th2 was significantly correlated with mean arterial pressure(MAP)and the urine proteinuria meansure in 24 hour in pre-eclampsia group(P<0.01 all). Conclusion Imbalance of Th1/Th2 might be the important reason of hypertensive disorder complicating pregnancy.更多还原