【摘要】 目的探讨吸氧预处理对大鼠脑缺血再灌注损伤的保护作用。方法通过大鼠局灶脑缺血再灌注损伤模型,采用SOD、MDA测定、电镜及神经行为学检查的方法,观察吸氧预处理对大鼠脑缺血再灌注损伤后SOD、MDA、神经行为学评分及脑组织病理变化。结果吸氧预处理组SOD活力高于对照组(P<0.05),MDA含量、神经行为学评分均低于对照组(P<0.05),脑组织超微结构损伤均减轻。结论吸氧预处理对大鼠脑缺血再灌注损伤有保护作用。更多还原

【Abstract】 Objective To investigate the protective action of oxygen-breathing pretreatment against brain ischemia-reperfusion injury in rats. Methods Using a model of focal brain ischemia-reperfusion in Sprague-Dowley rats, SOD activity and MDA level measurement, electron microscopy and neurological functional examination were performed to evaluate the protective role of oxygen-breathing pretreatment. Results Oxygen-breathing pretreatment showed a protective effect on brain ischemia-reperfusion injury. It presented significantly increased SOD level and decreased content of MDA. The ultrastructure of neurons in rats of oxygen-breathing pretreated group was ameliorated effectively. Conclusions Oxygen-breathing pretreatment has protective effect against brain ischemia-reperfusion injury.更多还原