【摘要】 目的:比较氯诺昔康和芬必得在下颌阻生智牙拔除术中的镇痛效果,评价氯诺昔康在下颌阻生智牙拔除术中的应用价值。方法:2004年3月～2005年1月期间,选择62例进行下颌阻生智牙拔除术的患者,随机平均分为氯诺昔康组和芬必得组,分别口服氯诺昔康片剂8mg,每天2次;芬必得片剂300mg,每天2次,连用3d。采用疼痛缓解程度记分法,对2种药物的镇痛效果进行记录,并进行组间t检验,比较2种药物的镇痛效果有无显著性差异。结果:术后2、24、72h各时间点进行组间t检验,t值分别为0.78、1.73、0.94,P>0.05,2组间疼痛缓解程度无显著性差异;术后4、8、12h各时间点进行组间t检验,t值分别为2.87、3.12、2.54,P<0.05,2组间疼痛缓解程度有显著性差异。结论:在缓解下颌阻生智牙拔除术后疼痛方面,氯诺昔康较芬必得镇痛效果更为明显,但可引起轻度的胃肠道症状。更多还原

【Abstract】 PURPOSE: This study is aimed to compare the analgesic results of lornoxicam with fenbid in patients undergoing extraction of the impacted mandibular third molar, and evaluate the role of lornoxicam in the extraction of the wisdom teeth. METHODS: 62 patients who visited our clinic from March 2004 to January 2005 with impacted mandibular third molar were divided into two groups randomly. Patients were given lornoxicam 8mg twice per day in the lornoxicam group, while in the fenbid group, fenbid 300mg twice per day were administrated continuously during 72 hours. Pain scores at 2h, 4h, 8h, 12h, 24h and 72h after surgery were recorded with PAR(pain relief) and Student’s t test was carried out for statistical comparison between the two groups. RESULTS: There were no significant differences in PAR between lornoxicam group and fenbid group at 2h, 24h, 72h after surgery (P>0.05). However, There were significant differences in PAR between lornoxicam group and fenbid group at 4h, 8h, and 12h after surgery (P<0.05). CONCLUSION: The study suggests that lornoxicam has more favorable analgesic efficacy than that of fenbid, but with mild side effect of gastrointestinal tract.更多还原