【摘要】 目的探讨高通量F50透析器和F6透析器的复用次数及其溶质清除效果。方法通过在线尿素清除率监测(OCM)测定60例患者,在其使用F50和F6透析器第1次及其复用第3、6、9次时Kt/V值的变化及透析器血室容积(Tcv)的数值。并对部分患者检测了透析前后血清尿素水平计算了Kt/V值。结果60例使用F50透析器的患者在第1次使用及其复用中,Kt/V值相互间比较均差异无显著。复用的F50透析器质量检测也全部合乎要求。使用F6透析器的患者在第1次使用及其复用中,Kt/V值相互间比较也均无显著下降。但F6透析器在复用至第9次时约90%的Tcv下降≥20%。检测的Kt/V值与OCM监测的Kt/V值比较无明显差别。结论F50透析器复用至第9次时,其质量和清除效果无明显改变。F6透析器复用至第9次时Kt/V值与第1次使用时比较下降无统计学差异,但大多透析器Tcv下降≥20%,故F6透析器复用不应用超过9次。更多还原

【Abstract】 Objective To explore reused dialyzer efficiency of high flux dialyzer F50and standard dialyzer F6 through on-line clearance measurement (OCM). Methods Kt/V value wasmeasured by OCM in sixty hemodilysis patients. Total column volume (Tcv) and pressure weremeasured after the dialyzers were used for the first, third, sixth and ninth time. ResultsKt/V value measured by OCM had no significant difference using reused F50 and F6 dialyzerscompared with new F50 and F6 dialyzers.There was no significant difference of Kt/V valuemeasured by OCM or by urea kinetic model. However, Tcv of 90% of the ninth time reused F6dialyzer decreased more than 20%. Conclusions Both clearance efficiency and hollow fiberquality of the ninth time reused F50 dialyzer do not markedly change compared to its firsttime using in hemodialysis, but Tcv of 90% the ninth time reused F6 dialyzer decrease morethan 20% though their Kt/V value does not decrease compared with new dialyzers.更多还原