【摘要】 目的探讨急性冠状动脉综合征(ACS)患者血尿酸(SUA)和总胆红素(TBil)及纤维蛋白原(FIB)含量与冠脉病变程度的关系。方法将136例ACS患者分为3组,其中急性ST段抬高心肌梗死(STEMI)患者42例(A组),急性非ST段抬高心肌梗死(NSTEMI)患者46例(B组),不稳定型心绞痛(UAP)患者48例(C组),同时选择45例正常体检者为对照组(D组),分别测定他们SUA、TBil和FIB的含量,并分析他们与冠脉病变程度的关系。结果ACS患者SUA和FIB含量均值分别为(374.0±26.5)μmol/L和(4.35±1.32)g/L,明显高于对照组SUA含量(258.6±18.4)μmol/L和FIB含量(2.26±0.82)g/L;而ACS患者TBil含量均值为(9.64±3.24)μmol/L,明显低于对照组的TBil含量(14.38±3.62)μmol/L;差异均具有显著性(P<0.01)。SUA和FIB均随冠状动脉病变程度的加重而增高,与之呈正相关(P<0.01);Bil水平随冠状动脉病变程度的加重而降低,与之呈负相关(P<0.01)。结论SUA和FIB含量的升高及Bil含量的降低与ACS的发生和冠脉病变严重程度密切相关,高SUA和FIB及低Bil是冠脉病变严重的独立危险因素。更多还原

【Abstract】 Objective To investigate the relationship between serum uric acid(SUA) , bilirubin(Bil), fibrinogen(FIB) and the severity of coronary heart disease (CHD) in patients with acute coronary syndromes(ACS). Methods One hundred thirty-six patients with ACS were divided into three groups: group A patients with STEMI(n=42); group B patients with NSTEMI(n=46); group C patients with UAP(n=48), 45 normal subjects(group D) served as control. The level of SUA ,TBil and FIB were determined. Results The levels of SUA and FIB in patients with ACS were (374.0±26. 5)μmol/L and (4.35±1.32)g/L, significantly higher than that of control group (258.6±18. 4)μmol/L and (2.26±0.82)g/L(P<0.01), The level of TBil in patients with ACS (9.64±3. 24)μmol/L was significantly lower than that of control group (14. 38±3. 62)μmol/L (P<0.01). The levels of SUA and FIB positively and the level of Bil negatively related with severity of CHD (P<0.01) . Conclusion The levels of elevated SUA and FIB, reduced Bil are closely related with ACS and the sererity of CHD.更多还原