【摘要】 目的了解静脉吸毒人群HIV血清抗体阳转率和队列本底的社会人口学和高危行为特征以及6个月随访情况与队列12个月保持率的关系。方法于2002年11月,在四川省西昌市从社区筛查HIV抗体阴性的静脉吸毒人群前瞻性研究队列333人。在队列每6个月随访时进行HIV抗体检测来估算HIV血清抗体阳转率和分析队列本底的社会人口学和高危行为特征以及6个月随访情况与队列12个月保持率的关系。结果静脉吸毒人群队列12个月的HIV血清抗体阳转率为3.17×10-2人年(95%CI=0.98~5.37)和保持率为70.3%。在多因素Logistic回归分析中,与队列12个月保持率差异有统计学意义的变量为6个月能随访到(OR=8.74,95%CI=4.95~15.41;P<0.0001)和彝族(OR=0.50,95%CI=0.28~0.87;P<0.0151)。未见静脉吸毒人群队列本底的HIV高危行为因素与队列12个月保持率的关系差异有统计学意义。结论静脉吸毒人群HIV血清抗体阳转率彝族和6个月未随访到的吸毒人群队列12个月的保持率低。更多还原

【Abstract】 Objective To understand HIV incidence and retention by subject’s baseline sociodemographic and behavioral characteristics in a 12-month follow-up study of injection drug users. Methods During November 2002,a community-based baseline survey was conducted to recruit 333HIV sero-negative injection drug users(IDUs) for a prospective cohort study in Xichang County of Sichuan Province,China. Results During the first 12-month follow-up period,HIV incidence was 3.17 per 100 person-years [95% confidence interval(CI):0.98,5.37].The retention rate at the 12-month follow-up visit was 70.3%.In a multiple logistic regression model,appearing at 6-month follow-up visit(OR=8.74,95% CI4.95～15.41;P<0.0001)and Yi ethnicity(OR=0.50,95% CI0.28～0.87;P<0.0151)were independently associated with retention in a 12month follow-up study of injection drug users.No drug using and sexual behaviors were found to be associated with retention at the 12-month follow-up visit. Conclusion There is a high HIV incidence among IDUs in Xichang County of Sichuan province,China;Yi ethnicity has a lower retention rate and appearing at 6-month follow-up visit may predict long-term retention rate in IDUs cohort,respectively.更多还原