【摘要】 目的观测营养性肥胖大鼠血浆肾上腺髓质素(ADM)水平变化以及心脏/体重、肝脏/体重比改变。方法用特异性放免法测定血浆ADM含量;称各组大鼠心脏、肝脏湿重,并分别计算与体重之比。结果肥胖大鼠血浆ADM水平(78.35±6.38)pg/ml明显低于正常体重大鼠(92.47±10.61)pg/ml(P<0.05);心脏(g)/体重(g)、肝脏(g)/体重(g)比(0.319±0.019),(3.334±0.410)均明显高于普通饲料喂养组(0.225±0.020),(2.951±0.730)(P<0.05)。结论营养性肥胖大鼠血浆ADM水平降低,在大鼠肥胖症的发生发展以及肥胖症大鼠心脏/体重、肝脏/体重比增大中可能起作用。更多还原

【Abstract】 Objective To observe the changes of adrenomedullin(ADM) level in plasma and heart/weight,liver/weight rate in nutrient obesity rats.Methods The concentration of ADM was determined by special radioimmunoassay,the weight of heart,liver and whole body were measured and the rate of heart/weight and liver/weight(g/g) were calculated respectively.Results The plasma ADM level in obesity rats(78.35±6.38)pg/ml was lower than that in normal rats(92.47±10.61)pg/ml(P<0.05);the rate of heart/weight(g/g)and liver/weight(g/g)of obesity rats(0.319±0.019),(3.334±0.410)were higher than those in normal groups(0.225±0.020),(2.951±0.730)(P<0.05).Conclusion Reduction of ADM level probably resulted in the occurrence and progression of nutrient obesity,and probably contributed to the increases of heart/weight and liver/weight.更多还原