【摘要】 目的了解病毒唑在体外抑制腺病毒3型(ADV3)作用的效果和强度。方法采用细胞病变抑制实验观察病毒唑在人宫颈癌传代(Hela)细胞中对腺病毒3型的抑制作用。结果病毒唑半数中毒浓度(TC50)为2056·13μg/ml;抑制腺病毒3型的半数有效浓度(EC50)为53·03μg/ml,治疗指数(TI)为38·77;病毒唑对腺病毒3型的抑制作用存在量效关系;在感染后10h以内给药,病毒唑能够有效地抑制腺病毒3型的复制。结论病毒唑在Hela细胞中对腺病毒3型有明显的抑制作用。更多还原

【Abstract】 Objective To study the inhibition action of the Ribavirin to Adenoviruses 3（ADV₃）.Methods The anti-ADV₃ effect of the ribaririn in Hela cell culture was observed by means of the inhibition of cytopathic effect.Results In cell culture,the Ribavirin was found to be a inhibitor of ADV₃ in a concentration-dependent manner toxic concentration（TC 50）of the Ribavirin was 2056.13?μg/ml,the median effective concentration（EC 50）of the Ribavirin to ADV₃ was 53.03?μg/ml,the selectivity index（TI）was 38.77.The Ribavirin could effectually inhibit replication of ADV₃ when it was added in Hela cell within 10 hours after virus infection.Conclusion The Ribavirin has the evident inhibition actions to ADV₃.更多还原