【摘要】 目的探讨β3AR基因多态性与高血糖人群膳食干预效果的关系,为糖尿病的膳食干预提供遗传学依据。方法从南京市8个社区抽取233名汉族高血糖者,随机分为复合干预组(154人)和对照组(79人)。干预组给予粗粮干预和进行健康进座,对照组不采取任何措施,试验周期6个月。结果干预组Trp/Trp基因型者体质指数(BMI)、腰臀比(WHR)、舒张压(DBP)、空腹血糖(FBG)、血总胆固醇(TC)水平明显降低,高密度脂蛋白胆固醇(HDLC)水平明显上升(P<0.05);Trp/Arg基因型组BMI、WHR、FBG水平明显降低,HDLC水平明显上升(P<0.05)。Arg/Arg基因型组无明显变化。此外,Trp/Trp型人群的BMI、WHR和FBG下降的干预效果明显大于Trp64Arg型和Arg/Arg型,而Trp64Arg型人群的这3项指标下降又明显大于Arg/Arg型(P<0.05)。结论高血糖人群膳食干预效果因β3AR基因型不同而有差异,其中,Trp/Trp人群对膳食干预效果最佳,Trp/Arg次之,而Arg/Arg效果较差。更多还原

【Abstract】 ObjectiveTo find out the relationship between a mutation in the β3-adrenergic receptor gene and the susceptibility of hyperglycemia population to dietary intervention,and to provide genetic evidence for intervention on diabetes mellitus.Methods 233 hyperglycemia individuals of Han were screened from 8 communities in Nanjing,and they were separated into multiplex nutritional intervention(154 individuals)and control group(79 individuals)at random.The former were provided with coarse good grain and health education for 6 months,and no any intervention for the latter.Results Body mass index(BMI),waist to hip ratio(WHR),diastolic blood pressure(DBP),fasting blood glucose(FBG),total cholesterol(TC) decreased significantly,while high density lipoprotein cholesterol(HDL-C)increased significantly(P<0.05)in the individuals with Trp/Trp of intervention group.BMI,WHR,FBG decreased significantly,HDL-C also increased significantly(P<0.05)in the ones with Trp/Arg.There was no significant changes in the ones with Arg/Arg.Moreover,susceptibility of change for BMI,WHR and FBG in Trp/Trp genotype carriers was greater than that in Trp/Arg or Arg/Arg genotype carriers.And,susceptibility of change for these 3 indexes in Trp/Arg genotpe carriers was greater than those in Arg/Arg genotype carriers(P<0.05).Conclusion Susceptibility of hyperglycemia population to dietary intervention varies with different genotypes of the β3-adrenergic receptor gene.Susceptibility of individuals with Trp/Trp to dietary intervention is the best of all,Trp/Trp takes second place,while Arg/Arg is relatively little.更多还原