【摘要】 目的探讨蒙古族人血浆肾素-血管紧张素系统的活性与原发性高血压的关系。方法在现况调查的基础上,分别征集高血压者和血压正常者。先按高血压家系、非高血压家系和家系不清分组,再进一步将人群分为3种家系中的高血压组和血压正常组。用放射免疫法测定血管紧张素Ⅰ(AngⅠ)、血管紧张素Ⅱ(AngⅡ)和血浆肾素活性(PRA)。结果AngⅠ、AngⅡ和PRA在3种家系中总体比较差异均有统计学意义(P<0.001)。AngⅠ和AngⅡ不仅在3种家系的两组中比较差异有统计学意义(P<0.05),而且在高血压家系中的高血压组和非高血压家系中的正常组、家系不清中的正常组间比较差异也具有统计学意义(P<0.05)。PRA仅在高血压家系的两组中比较差异有统计学意义(P<0.05)。结论在蒙古族人群中,AngⅠ、AngⅡ和PRA与原发性高血压的发生可能有关。PRA与高血压家族遗传史可能有一定的关联。更多还原

【Abstract】 Objective To explore the association between activity of renin-angiotensin system and essential hypertension in Mongolian people in China.Methods Based on a previous survey,450 hypertensives and 590 normotensives were recruited as study.They were divided into three pedigree groups according to genealogy of hypertension,i.e.,hypertensive,non-hypertensive and unknown ones,and each group subdivided into hypertensive cases & normal controls.Radioimmunoassay(RIA) was utilized to measure levels of angiotensin Ⅰ(Ang Ⅰ),angiotensinⅡ(Ang Ⅱ)and plasma rennin activity(PRA),respectively.Results There was significant difference in plasma level of Ang Ⅰand Ang Ⅱ and PRA in three pedigree groups(P<0.001).Not only significant difference in levels of Ang Ⅰ and Ang Ⅱ between the hypertensives and normotensives in three pedigree(P<0.05) was observed,but also significant difference in Agn Ⅰ and Ang Ⅱ was observed between the hypertensives in hypertensive pedigree and the normotensives in non-hypertensive pedigree,respectively(P<0.05).There was significant difference only in plasma level of PRA between the hypertensive and normotensive group of hypertensive genealogy(P<0.05).Conclusion Plasma level of Ang Ⅰ,Ang Ⅱ and PRA may be related to hypertension in Mongolian people,and PRA seems to be correlated with family history hypertension.更多还原