【摘要】 目的:研究不同年龄阶段和不同体重指数的PCOS患者糖耐量异常的发生率,探讨糖代谢异常与年龄、体重的关系。方法:495例PCOS患者,口服75 g葡萄糖,行糖耐量及胰岛素释放实验。用卡方检验及偏相关分析方法比较不同年龄与体重的PCOS患者糖耐量的差异。结果:495例患者中糖尿病发生率为4.0%(20例),糖耐量低减的发生率为16.6%(82例);根据胰岛素敏感性指数分析,胰岛素敏感性高者275例,占55.6%,胰岛素敏感性低者220例,占44.4%;偏相关分析发现,不同年龄段的PCOS患者糖尿病和糖耐量低减的发生率不同,两者呈正相关,r=0.172,有统计学差异(P=0.000),不同年龄患者的胰岛素敏感性相比,无显著性差异;不同体重指数的PCOS患者糖尿病发生率和糖耐量低减的发生率不同,两者呈正相关,r=0.318,有统计学差异(P=0.000),胰岛素敏感性相比,两者呈负相关,r=-0.434,有显著性差异(P=0.000)。结论:PCOS患者随着年龄和体重的增加,糖耐量异常的发生率增加;肥胖患者的胰岛素抵抗更严重。更多还原

【Abstract】 Objective:To study the prevalence of impaired glucose tolerance(IGT) and diabetes mellitus(DM)in women with polycystic ovary syndrome(PCOS) with different age and body mass index(BMI) and to assess the effect of the age and BMI on glucose metabolism.Methods:Glycemia and insulin(INS) response to the tolerance test with 75 g oral glucose load were assessed in 495 PCOS patients.The difference in IGT of PCOS patients with different age and BMI were compared with chi squar test and partial correlation analysis.Results:The prevalence of type2 DM and IGT was 4.0% and 16.6%.There were 275 cases with higher insulin sensitivity(55.6%),220 cases with lower insulin sensitivity(44.4%) according to insulin sensitivity index analysis.Age was positive correlated with the prevalence of type2 DM and IGT(r=0.172,P=0.000),older women had significant higher abnormality of glucose metabolism,but there was no significance in insulin sensitivity among the different ages.BMI was positive correlated with the prevalence of type2 DM and IGT(r=0.318,P=0.000),BMI was negative correlated with insulin sensitivity(r=-0.434,P=0.000).Conclusion:The prevalence of type2 DM and IGT significantly increased with age and BMI;obese PCOS women had worse insulin resistance.更多还原