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宫颈病变DNA倍体分析及临床意义

The assessment and clinical significance of DNA ploidy analysis in cervical lesions

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【作者】 宋改环朱宇朱凤全田庚

【Author】 SONG Gai-Huan,ZHU Yu,ZHU Feng-Quan,et al.The Second Hospital of Jilin University,Changchun 130041,China

【机构】 吉林大学第二医院吉林大学第二医院 130041130041130041

【摘要】 目的:探讨DNA异倍体与宫颈上皮内瘤样病变及宫颈癌之间的关系。方法:宫颈鳞癌40例,宫颈上皮内瘤样病变81例(C INⅠ-Ⅱ级42例,C IN-Ⅲ级39例),慢性宫颈炎30例行流式细胞仪DNA倍体分析。正常宫颈组20例作为对照。结果:C INⅠ-Ⅱ级、C IN-Ⅲ级、宫颈癌组DNA异倍体率呈上升趋势,且各组间有显著性差异(P<0.05,P<0.01),C INⅠ-Ⅱ级、C IN-Ⅲ级DNA异倍体D I值与宫颈癌组比较有显著性差异(P<0.001),C INⅠ-Ⅱ级、C IN-Ⅲ级D I值比较有显著性差异(P<0.05)。结论:应用FCM进行DNA倍体分析对于宫颈癌的诊断、预后判断及上皮内瘤样病变恶性倾向的判断、治疗及随访有着非常积极的临床意义。

【Abstract】 Objective:To discuss the relationship of DNA aneup in group of fetus that were ill pregnanted loid and cervical intraepithelial neoplasia、cervical cancer.Methods:40 cases cervical squamous carcinoma,81 cases cervical intraepithelial neoplasia(42 cases CIN Ⅰ-Ⅱ,39 cases CIN Ⅲ)and 30 cases chronic cervicitis were subjected to DNA ploidy analysis and the normal cervical tissues were control groups.Results:An increasing trend of DNA aneuploidy and DI value in DNA aneuploidy cell was observed from CINⅠ-Ⅱ to CIN Ⅲ to cervical cancer.Conclusion:The significance of DNA ploidy measurement is related to diagnosis of cervical cancer,prediction of patients’ prognosis and treatment,DNA ploidy also act as a high risk indicator in cervical intraepithelial neoplasia.

【关键词】 流式细胞仪DNA倍体宫颈癌
【Key words】 Flow cytometryDNA poidyCervical cancer
  • 【文献出处】 中国妇幼保健 ,Maternal and Child Health Care of China , 编辑部邮箱 ,2005年20期
  • 【分类号】R737.33;
  • 【被引频次】5
  • 【下载频次】116
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