【摘要】 目的:探讨DNA异倍体与宫颈上皮内瘤样病变及宫颈癌之间的关系。方法:宫颈鳞癌40例,宫颈上皮内瘤样病变81例(C INⅠ-Ⅱ级42例,C IN-Ⅲ级39例),慢性宫颈炎30例行流式细胞仪DNA倍体分析。正常宫颈组20例作为对照。结果:C INⅠ-Ⅱ级、C IN-Ⅲ级、宫颈癌组DNA异倍体率呈上升趋势,且各组间有显著性差异(P<0.05,P<0.01),C INⅠ-Ⅱ级、C IN-Ⅲ级DNA异倍体D I值与宫颈癌组比较有显著性差异(P<0.001),C INⅠ-Ⅱ级、C IN-Ⅲ级D I值比较有显著性差异(P<0.05)。结论:应用FCM进行DNA倍体分析对于宫颈癌的诊断、预后判断及上皮内瘤样病变恶性倾向的判断、治疗及随访有着非常积极的临床意义。更多还原

【Abstract】 Objective:To discuss the relationship of DNA aneup in group of fetus that were ill pregnanted loid and cervical intraepithelial neoplasia、cervical cancer.Methods:40 cases cervical squamous carcinoma,81 cases cervical intraepithelial neoplasia(42 cases CIN Ⅰ-Ⅱ,39 cases CIN Ⅲ)and 30 cases chronic cervicitis were subjected to DNA ploidy analysis and the normal cervical tissues were control groups.Results:An increasing trend of DNA aneuploidy and DI value in DNA aneuploidy cell was observed from CINⅠ-Ⅱ to CIN Ⅲ to cervical cancer.Conclusion:The significance of DNA ploidy measurement is related to diagnosis of cervical cancer,prediction of patients’ prognosis and treatment,DNA ploidy also act as a high risk indicator in cervical intraepithelial neoplasia.更多还原