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恩丹西酮和地塞米松预防小儿术后恶心呕吐的临床研究

The prophylactic against postoperatively nausea and vomiting of ondan-setron combined with Dexamethasone in children

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【作者】 刘付小军曹殿青莫坚

【Author】 LIUFU Xiao-jun,CAO Dian-qing,MO Jian. Department of Anesthesiology,Affiliated Hospital,Guangdong medical college,Zhanjiang 524001,China

【机构】 广东医学院附属医院麻醉科广东医学院附属医院麻醉科 524001524001524001

【摘要】 目的:研究恩丹西酮和地塞米松预防小儿术后恶心呕吐(PONV)的临床效果。方法:选择120例手术患儿分4组,每组30例。Ⅰ组:静注生理盐水;Ⅱ组:地塞米松0.1mg/kg;Ⅲ组:恩丹西酮0.1mg/kg;Ⅳ组:地塞米松0.1mg/kg加恩丹西酮0.1mg/kg。比较各组患儿PONV的发生率。结果Ⅱ、Ⅲ、Ⅳ组PONV发生率明显低于Ⅰ组(P<0.005),Ⅳ组也明显低于Ⅱ、Ⅲ组(P<0.005),Ⅱ、Ⅲ组间无明显差异(P0.005)。结论:恩丹西酮和地塞米松均可有效预防小儿PONV,两药联合应用效果更佳。

【Abstract】 Objective:To explore the prophylactic effect against PONV(postoperatively nausea and vomiting)of Ondansetron combined with Dexamethasone in children.Methods:120 children patients were selected and divided into 4 groups randomly (n=30). All the patients were given saling 2 ml intravenously in Group Ⅰ,Dexamethasone 0.1 mg/kg in GroupⅡ,Ondansetron 0.1 mg/kg in Group Ⅲ and Dexamethasone+Ondansetron (0.1 mg/kg) in GroupⅣ. The rate of PONV in each group was recorded and analyzed statistically. Results:The rate of PONV in Group Ⅱ,Ⅲ and Ⅳ was significantly lower than that in Group Ⅰ(P<0.005) and it was lower in Group Ⅳ than that in Group Ⅱ or in Group Ⅲ(P<0.005),however,there was no significant difference between Group Ⅱ and Group Ⅲ(P0.005).Conclusion:Ondansetron or Dexamethasone can prevent PONV in children and combined use of two drugs is more effective.

【关键词】 恩丹西酮地塞米松术后恶心呕吐小儿
【Key words】 OndansetronDexamethasonePONVChildren
  • 【文献出处】 中国妇幼保健 ,Maternal and Child Health Care of China , 编辑部邮箱 ,2005年14期
  • 【分类号】R726.1
  • 【被引频次】1
  • 【下载频次】42
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