【摘要】 目的探讨乏氧诱导因子-1α(HIF-1α)在非小细胞肺癌中的表达水平及其临床意义。方法采用免疫组织化学技术检测乏氧诱导因子-1α在68例非小细胞肺癌标本中的表达。结果(1)HIF-1α在非小细胞肺癌中的总的阳性表达率为57.35%(39/68);(2)腺癌中HIF-1α的阳性表达率为54.76%(23/42),鳞癌中HIF-1α的阳性表达率61.54%(16/26),腺癌与鳞癌之间HIF-1α的阳性表达率无显著差异(P>0.05);中高分化的肿瘤标本中HIF-1α的阳性表达率为74.28%(26/35)高于低分化的肿瘤标本中HIF—1α的阳性表达率39.39%(13/33)(P<0.05);(3)HIF-1α的表达与性别、年龄及有无淋巴结转移和临床分期无关。结论HIF-1α在非小细胞肺癌中有着较高的表达率,且与肿瘤的分化程度有一定的关系。更多还原

【Abstract】 Objective: To explore the expression level and its clinical significance of hypoxia inducible factorlα (HIF-lα) in non-small lung cancer. Methods: The expression of HIF-lα was detected in 68 humannon-small lung cancer samples by immunohistochemistry. Results: (1) Thirty-nine (57.35%) out of the 68human non-small lung cancer samples was positive for HIF-lα; (2) The positive rate of HIF-lα in adeno-carcinoma and squamous carcinoma was 54.76% (23/42) and 61.54% (16/26) respectively. No significantdifference was found between adenocarcinoma and squamous carcinoma of non-small lung cancer in theexpression of HIF-lα (P>0.05). The positive rate of HIF-lα in middle-high differentiation was 74.28%(26/35), significantly higher than in low differentiation (39.39%, 13/33) (P<0.05); (3) The positive expres-sion of HIF-lα was not correlated to the sexes, ages, tumor stage and lymph node status. Conclusion:The expression of HIF-lα is higher in non-small lung cancer and is correlated to differentiation.更多还原