【摘要】 目的探讨肺癌中E钙粘蛋白的表达和微血管密度的关系及意义。方法用SP免疫组化技术检测E钙粘蛋白和Ⅷ因子在104例肺癌组织中的表达,利用图象分析系统计算微血管密度。结果E钙粘蛋白与肺癌分级有密切关系,随分化程度的降低,E钙粘蛋白的阳性率明显下降(P<0.05),且呈现异常表达。E钙粘蛋白表达还与肺癌组织微血管密度呈显著负相关(P=0.047)。结论E钙粘蛋白表达的降低和微血管密度的增加可能在促进肺癌浸润转移中起重要作用。更多还原

【Abstract】 Objective: To study the relationship between the expression of E-cadherin and microvessel density (MVD) in lung cancer. Methods: The expression of E-cadherin and factor Ⅷ was detected in 104 lung cancer tissues by an immunohistochemical method, and MVD was calculated by an image-analysis system. Results: The expression of E-cadherin was significantly related to the differentiation of lung cancers (P<0.05). A negative correlation was found between E-cadherin expression and MVD in lung cancer tissues (P=0.047). Conclusion: Down-expression of E-cadherin and an increase of MVD may play an important role in the invasion and metastasis of lung cancer, and may also be used as a useful marker for tumor prognosis.更多还原