【摘要】 目的研究积雪草Centella asiatica的化学成分。方法采用各种色谱技术进行分离纯化,通过理化性质和波谱分析进行结构鉴定。结果从积雪草中共分离得到14个化合物,其结构鉴定为β-谷甾醇(Ⅰ)、二十六醇辛酸酯(Ⅱ)、山柰酚(Ⅲ)、槲皮素(Ⅳ)、胡萝卜苷(Ⅴ)、香草酸(Ⅵ)、丁二酸(Ⅶ)、积雪草酸(Ⅷ)、羟基积雪草酸(Ⅸ)、ter-minolic acid(Ⅹ)、积雪草苷(Ⅺ)、积雪草二糖苷(Ⅻ)、羟基积雪草苷、积雪草苷-B。结论化合物为一新化合物;羟基积雪草酸和terminolic acid、羟基积雪草苷和积雪草苷-B为两对同分异构体。更多还原

【Abstract】 Objective To study the chemical constituents in Centella asiatica. Methods Isolation by use of various chromatographic techniques, structure identification by their physico-chemical properties as well as various spectral data. Results The structures of 14 constituents in C. asiatica were determined, which were β-sitosterol (Ⅰ), hexacosanol octanoate (Ⅱ), kaempferol (Ⅲ), quercetin (Ⅳ), daucosterol (Ⅴ), vanillic acid (Ⅵ), succinic acid (Ⅶ), asiatic acid (Ⅷ), madecassic acid (Ⅸ), terminolic acid (Ⅹ), asiaticoside (Ⅺ), asiaticodiglycoside ( ⅩⅡ ), madecassoside ( ⅩⅢ ), asiaticoside-B ( ⅩⅣ ). Conclusion Compound ⅩⅡ is a new compound. Madecassic acid and terminolic acid, madecassoside and asiaticoside-B are two couples of isomeric compounds.更多还原