【摘要】 目的优选成型所需辅料,确定通络微丸成型方法。方法对不同辅料制备的微丸成型难易、流动性、溶出度等比较,筛选出适当的成型辅料,并确定旋转制丸的工艺参数。结果10PEG2000制丸模和5PEG2000或10的阿拉伯胶加大时,该浸膏粉成丸效果较好,微丸的圆整性、流动性、溶出度均较好。微丸加大成型的适宜参数是主机转速100r·min-1,鼓风压力0.04MPa,喷浆速度300g·min-1,饲粉速度1200g·min-1。结论粘合剂的品种选择是中药浸膏粉制备微丸的关键,旋转式制丸技术制备微丸时加大成型的参数应适宜。更多还原

【Abstract】 AIM: To choose the proper excipient for molding process of Tongluo Mini-Pill (Radix Astragali,Radix Augelicae sinensis,Flos longicerae Japonicae,etc) and couplet its production. METHODS: A variety of excipients properties such as fluidity,solubility and dissolution were compared to select and determine the processing parameters of rotary perlletizer. RESULTS: Recommendation was made applying processing parameters that 10% PEG_ 2000 ,10% PEG_ 2000 or 10% gum arabic used for excipient,pelletizer had a rotational velosity of 100 rpm.pressure of 0.04 Mpa and feeding rate of 1200 g·min -1 . CONCLUSION:Selection of excipients is a key to make Tonglu Mini-Pill.更多还原