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金柴小儿肺炎颗粒药效学研究

Pharmocodynamics of Jinchai Xiaoer Feiyan Granule

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【作者】 孙玉华黄华杨丽丽哈木拉提崔晓兰刘发

【Author】 SUN Yu-hua1, HUANG Hua1, YANG Li-li1, Hamulati1, CUI Xiao-lan2, LIU Fa1 (1. Xinjiang Institue of Materia Medica, Urumqi 830002, China; 2. Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicines, Beijing 100700, China)

【机构】 新疆维吾尔自治区药物研究所中国中医研究院中药研究所新疆维吾尔自治区药物研究所 新疆乌鲁木齐830002新疆乌鲁木齐830002北京100700新疆乌鲁木齐830002

【摘要】 目的:研究JCG体内外抗菌和抗病毒作用.方法:用体外抗菌及病原菌感染小鼠造模检测抗菌作用;用细胞培养和 小鼠流感病毒性肺炎模型研究对病毒的抑制作用等;小鼠扭体模型研究镇痛;小鼠气管酚红排泌量模型研究祛痰。结 果:体内外试验表明JCG对肺炎球菌有较好的抑菌和杀菌作用。对呼吸道多种病毒所致细胞病变均有明显抑制作用。 三剂量使流感病毒致小鼠肺炎模型的肺指数值、肺病变程度明显轻于病毒对照组(P<0.05)。结论:JCG对呼吸道常见 感染菌、病毒有抑杀作用,并有解热、止痛、祛痰、镇咳作用。

【Abstract】 AIM: To observe the effect of JXFG(Radix Bupleuri, Radix Seutellariae, etc.) on anti-bacteria and anti-virus actions. METHODS: Tube culture was used to study the anti-bacteria effect of JXFG. The model of mouse infected by pathogenic bacteria was established to examine the anti-bacteria effects of JXFG. RESULTS: The anti-bacteria experiments of JXFG in vitro and vivo showed that JXFG had strong an effect on inhibiting pneumococcus. It had significant the effect of inhibiting cells pathologic change induced by varies varies common respiratory virus. CONCLUSION: JXFG hax the effect of inhibiting common bacteria and virus of respiratory tract, and has the effect of resolving heat, relieving pain, analgesia, removing phlegm and relieving cough.

  • 【文献出处】 中成药 ,Chinese Traditional Patent Medicine , 编辑部邮箱 ,2005年02期
  • 【分类号】R285.6
  • 【被引频次】5
  • 【下载频次】176
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