【摘要】 目的:探讨糖尿病小鼠肝脏SR-B1表达变化,及其与血脂的关系。方法:进正常食C57BL/6J小鼠10只、进高脂高糖食8周小鼠5只、进高脂高糖食16周小鼠10只,测定血脂、血清胰岛素(INS)、空腹血糖(FBG),及肝脏SR-B1蛋白表达。结果:①高脂高糖食16周的小鼠血清甘油三酯(TC)、FBG明显高于正常小鼠(P<0·05),其胰岛素水平与正常小鼠无显著差异(P>0·05)。②高脂高糖食小鼠肝脏SB-B1表达高于正常动物,16周强于8周的小鼠。结论:糖尿病小鼠肝脏SR-B1表达高于正常小鼠,血清HDL-C降低可能与肝脏的SR-B1蛋白表达增高有关。更多还原

【Abstract】 AIM: To investigate serum lipid and the expression of SR-B1 in the livers of diabetic mice. METHODS: Ten normal diet, female C57BL/6J mice, fifteen high fat and sugar diet female C57BL/6J mice, five fed 8 weeks and ten fed 16 weeks were used in the experiment. Serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), insulin (INS) and the expression of SR-B1 in the livers were measured. RESULTS: 1. In the high fat and sugar diet mice, serum TC and FBG at 16 weeks were significantly higher than that in normal diet mice (P<0.05). 2. The expression of SR-B1 protein in the liver of high fat and sugar diet mice was the higher than that in normal mice, and the SR-B1 expression in the liver of the mouse fed 16 weeks was also higher than that fed 8 weeks. CONCLUSION: The expression of SR-B1 protein in the liver of type 2 diabetes mice is higher than that in normal mice, perhaps it is related to the decrease in serum HDL-C.更多还原