【摘要】 目的:探讨白藜芦醇(RES)对去卵巢大鼠骨密度(BMD)的影响。方法:48只SD大鼠随机分为6组,分别接受假手术(A)、去卵巢(B)、去卵巢+0.03mg/(kgbw·d)己烯雌酚(DES,C)、去卵巢+RES5、15和45mg/(kgbw·d)(D,E,F)90d后,用双能X线吸收法测定大鼠的骨密度,观察其改变。结果:B组大鼠各BMD测定指标均显著低于A组,D、E、F组全身和腰椎BMD均显著高于B组,E、F组整体股骨BMD显著高于B组。结论:白藜芦醇对去卵巢大鼠的骨丢失有抑制作用,以45mg/(kgbw·d)剂量对骨密度的保护效果最好。更多还原

【Abstract】 Objective: To investigate the effects of resveratrol(RES)on the bone mineral density (BMD) in ovariectomized female rats. Method: Forty-eight SD female rats were randomly divided into 6 groups and treated respectively as follows:group A, sham operated; group B, ovariectomized (OVX); group C, OVX supplemented with 0.03 mg/(kg bw ·d)diethylstilbestrol; and group D, E , F: OVX rats supplemented with RES at 5, 15 and 45 mg(/kg bw ·d). The duration of exposure was 90 d and the BMDs of rats were measured by dual-energy X-ray absorptiometry (QDR-4500A). Results: BMDs at all measured sites of group B were significantly lower than those of group A. And compared with group B, BMDs of the total body, lumbar vertebrae and femur of group D, E, F were increased significantly by RES. Conclusion: The bone loss of the ovariectomized female rats could be inhibited by RES. It seemed that the inhibitory effects of 45 mg/(kg bw ·d)RES on bone loss of ovariectomized female rats were better than the other 2 dosages or 0.03 mg/(kg bw ·d)diethylstilbestrol in this experiment.更多还原