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可降解聚酯多孔支架的常温模压成型
A "Room-Temperature" Compression Molding Method for Fabrication of Poly (ε-caprolactone) Porous Scaffolds
【Abstract】 A novel room-temperature compression molding method combined with particulate leaching was(developed) to fabricate porous polyester scaffolds with the anatomical shape of the tissue or organ potentially(applied) in tissue engineering.Complicated-shaped scaffolds,such as auricle-like ones,were successfully fabricated from compression-molding putty-like mixture of concentrated poly(ε-caprolactone) solution and salt particulate in a mould with a complicated-shaped cavity at room temperature.The resultant porosity can reach over 90%.This room-temperature compression molding method is proven to be very convenient to fabricate three-dimensional porous scaffolds composed of biodegradable polymers.
【关键词】 组织工程；
多孔支架；
可降解聚合物；
聚ε-己内酯；
聚合物加工；
【Key words】 tissue engineering； porous scaffold； biodegradable polymer； poly(ε-caprolactone)； polymer processing；
【Key words】 tissue engineering； porous scaffold； biodegradable polymer； poly(ε-caprolactone)； polymer processing；
【基金】 国家自然科学基金资助项目(20221402,20374015);教育部科学技术研究重大项目(305004);高等学校青年教师教学和科研奖励基金;“九七三”项目、“八六三”项目(2004AA215170);上海市科技发展基金(04JC14019)资助
- 【文献出处】 应用化学 ,Chinese Journal of Applied Chemistry , 编辑部邮箱 ,2005年09期
- 【分类号】R318.08;
- 【被引频次】3
- 【下载频次】166