【Abstract】 Demecolcine was synthesized from colchicine in two steps. The methylation of colchicine with （iodomethane） was carried out in a THF solution of potassium t-butoxide at -20 ℃ for 4 h. The product was （isolated） on a silica gel flash column with a yield of over 78%. N-Methylcolchicine was then （hydrolyzed） in （i-propanol） and aqueous solution of sodium hydroxide under refluxing temperature to give （demecolcine）. The （overall） yield was 69%. The structures of the two products were confirmed by IR and ¹H NMR.更多还原