【Abstract】 Intermediate 6-cyanoindole was obtained from 4-methylbenzonitrile as a raw material via nitration with the mixed acid, condensation with N,N-dimethylformamide dimethyl acetal and cyclic reaction with Raney nickel-hydrazine. 6-Cyanoindole-3-carboxyaldehyde was synthesized via the Vilsmeier reaction of 6-（cyanoindole） with N,N-（diemthylformamide） and phosphorus oxychloride. The structure of the target compound was confirmed by ¹H NMR, IR and elemental analysis. The total yield was 57% and the purity of the final （product） reached 99.4%.更多还原