【摘要】 目的:建立测定萘普生缓释片中萘普生含量的高效液相色谱法。方法:分析柱为HiQsilC18柱(4.6mm×250mm,5μm),流动相为0.02mol/L磷酸二氢钾溶液(pH=3.5)-甲醇-乙腈(3∶4∶3),流速为1.0mL/min,检测波长为275nm。结果:萘普生线性范围是26～156μg/mL,平均回收率为98.8%,RSD=1.47%(n=9)。结论:高效液相色谱法简便快速、准确可靠,可用于萘普生缓释片中萘普生的含量测定。更多还原

【Abstract】 Objective:To establish an HPLC method for determination of the content of naproxen in naproxen sustained release tablet. Methods:Stationary phase was HiQ sil C18 (4.6 mm×250 mm,5 μm),mobile phase was mixture of 0.02 mol/L phosphate solution(pH=3.5)-methanol-acetonitrile(3 ∶4 ∶3),detection wavelength 275 nm,flow rate 1.0 mL/min.Results:There was good linearity within the con-centration range of 26～156 μg/mL for naproxen,the average recovery of naproxen was 98.8%(RSD=1.47%,n=9).Conclusion:The method is rapid and accurate.It can be applied to effective quality control of naproxen sustained release tablet.更多还原