【摘要】 目的研究脑损伤大鼠血浆及肾组织匀浆中孤啡肽含量变化及急性肾损害中的作用。方法提高建立大鼠脑损伤模型,用RIA方法测定血浆及肾组织匀浆中孤啡肽含量。结果大鼠脑外伤组血浆及肾组织匀浆中孤啡肽含量明显高于对照组。结论孤啡肽含量变化在脑外伤后急性肾损害过程中起重要作用。更多还原

【Abstract】 Objective Study on the changes of Orphanin FQ in the plasma and nephridium organizes of rat with Brian trauma, and to explore the effects of Orphanin FQ on acute nephridium injury. Methods build up a model of rat with brian trauma,and then determined the Levels of Orphanin FQ in the plasma and nephridium organizes by RIA method. Results The levels of PACAP in the plasma of rat with brian trauma was significantly higher than that in control group( P <0. 01). and the Levels of Orphanin FQ in the nephridium organizes of rat with Brian trauma was lower than that in control group( P <0.01). Conclusion Orphanin FQ may be an important factor in the process of acute nephridium injury after brian trauma.更多还原