【摘要】 目的探讨血液透析对尿毒症患者胃肠运动功能障碍的影响。方法应用胃肠测压技术对26名尿毒症患者在进入透析前(尿毒症组)及充分透析4周后(治疗组)进行了消化间期移行性复合运动(MMC)检测,连续测定240min;应用放射免疫法检测了上述人员的空腹血浆胃动素水平;有8名尿毒症患者进行了电子胃镜检查。结果①尿毒症组MMC Ⅰ期、Ⅱ期出现的比例明显高于治疗组13.3%,尿毒症组有MMCⅢ期者仅19.2%,明显低于治疗组77%,(χ~2=18.6,P<0.01);②在有MMCⅢ期患者中,尿毒症组胃窦和十二指肠的收缩频率明显低于治疗组(t=3.3～12.4,P<0.05,P<0.01);③尿毒症组空腹血浆胃动素水平明显高于治疗组(t=19.6,P<0.01);④8名行胃镜检查的尿毒症患者中,6人为慢性浅表性胃炎,2人为贫血性胃改变。结论尿毒症患者存在胃肠运动功能障碍,主要表现为MMC 的异常和高胃动素血症。血液透析可改善尿毒症患者的胃肠运动功能障碍。更多还原

【Abstract】 Objective To study the effects of hemodialysis(HD)on disturbance of gastrointestinal movement function in patients with ure- mia.Methods The migrating motor complex(MMC)and motilin of 26 patients with uremia were measured before HD and after sufficient HD 4 week.Results ①MMCⅠ,Ⅱ of uremia patients were appeared higher frequency than that of the treat group(P<0.01),MMC Ⅲ of uremia patients were signifiearit lower than that of treat group(x~2=18.6,P<0.01);②the contractive frequency of antral and duodenal in uremia patients with MMC Ⅲ was significant lower than that of treat group(t=3.3～12.4,P<0.05,P<0.01),limosis motilin of uremia patients were higher than that of treat group(t=19.6,P<0.01).Concluson Uremia patients have a disturbance of gastrointestinal movement func- tion,and the essential manifestation is MMC abnormity and high level motilin in plasma.The disturbance of gastrointestinal movement function were able to improved by HD.更多还原