【摘要】 目的应用超声心动图技术,探讨人骨髓间质干细胞移植于大鼠梗死心肌后的作用。方法在M型超声心动图上,对实验组和对照组大鼠进行左心腔大小,室间隔、室壁心肌厚度,收缩运动幅度及左室射血分数测量。结果实验组的室间隔运动明显优于对照组,两组室间隔与左室后壁运动幅度之比存在显著性差异。结论实验组室间隔心肌收缩运动改善。提示人骨髓间质干细胞有心肌重建的作用,超声心动图可用于大鼠心脏实验研究。更多还原

【Abstract】 Objective To assess the role of transplantation of human bone marrow mesenchymal stem cells (MSCs) to the infarcted myocardium in rats with echocardiography. Methods M-mode echocadiography was used to measure the size of left ventricular cavity, the thickness of interventricular septum and ventricular wall, and the amplitude of movement of ventricular wall and the left ventricular ejection fraction. Results The movement of interventricular septum in trial group is superior to that in control group. The amplitude of movement of inter-vetricular septum and left ventricular posterior wall is significantly different between two groups. Conclusion The movement of interventricular septum has been improved significantly in the trail group. It suggests that MSC could reconstruct the infarcted myocardium and echocardiography could be used to monitor the experimental rat heart.更多还原