【摘要】 目的研究雷公藤（Tripterygium wilfordii Hook.F.）的化学成分。方法应用各种色谱技术进行分离纯化,用 UV,IR,¹H NMR,MS,HRMS,¹H-¹H COSY,¹H-¹³C COSY 和 NOESY 等光谱鉴定化合物的结构。结果共分离得到4个化合物:Ⅰ为16-羟基雷公藤内酯醇（16-hydroxytriptolide）,Ⅱ为15-羟基雷公藤内酯醇（雷醇内酯,triptolidenol）,Ⅲ为雷公藤乙素（tripdiolide）,Ⅳ为雷公藤乙素的差向异构体,命名为2-表雷公藤乙素（2-epitripdiolide）。结论化合物Ⅳ为新二萜内酯化合物。更多还原

【Abstract】 Aim To study the chemical constituents of Tripterygium wilfordii Hook.F.Methods Various column chromatographies with silica gel were used for the isolation and purification.The structures of compounds were established on the basis of its IR,MS,UV,¹H NMR,¹³C NMR and HRMS,¹H-¹H COSY,¹H-¹³C COSY and NOESY.Results Four diterpenoids were isolated: 16-hydroxytriptolide（Ⅰ）, triptolidenol（Ⅱ）,tripdiolide（Ⅲ）,2-epitripdiolide（Ⅳ）.Conclusion Compound Ⅳ is a new diterpenoid.更多还原