【摘要】 目的探讨早期较大剂量辛伐他汀治疗不稳定型心绞痛(UAP)的临床有效性及安全性。方法将84例UAP随机分成两组,对照组常规治疗,治疗组在常规治疗基础上口服辛伐他汀40 mg,1次/d。观察治疗后心绞痛缓解、心电图改善、血脂变化及不良反应。结果治疗组心绞痛临床缓解、心电图改善总有效率分别88.6%、93.2%,与对照组比较有显著差异。治疗组8周后血TC、LDL-C分别下降20.66%、19.44%。结论辛伐他汀40 mg/d早期强化治疗UAP安全有效,能显著降低血脂,心绞痛临床缓解、心电图改善明显。更多还原

【Abstract】 Objective To investigate the efficacy and safety of early use of higher dosage of simvastatin in patients with unstable angina pectoris(UAP).Methods 84 patients with UAP were divided randomly into two groups: treatment group and control group.All patients received the routine treatment except that simvastatin(40 mg/d) was administered to treatment group.Alleviation of angina pectoris,ECG,TC,LDL-C and side effects were recorded after treatment.Results In treatment group,88.6% patients showed angina pectoris alleviated,93.6% patients showed ECG improved,TC was decreased by 20.66% and LDL-C by 19.44% at the 8th week after treatment.There was significant difference between two groups.Conclusion Early use of simvastatin in patients with UAP is safe and effective.更多还原