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Synthesis, Characterization and Antitumor Activity of Lanthanum(Ⅲ) Complex with Demethylcantharidate

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【Author】 Yin Fuling ~*, Zou Jiajia , Xu Ling , Wang Xu , Li Rongchang (Department of Chemical Biology, School of Pharmaceutical Science, Peking University, Beijing 100083, China)

【机构】 Department of Chemical Biology； School of Pharmaceutical Science； Peking University； Beijing 100083； China； China；

【Abstract】 A novel complex of lanthanum（Ⅲ） with demethylcantharidate group （DCA）, Na[La（DCA）₂（H₂O）], was synthesized in aqueous solution and characterized by elemental analysis, molar conductance, IR, UV, ¹H-NMR spectra and TG-DTA. The results suggest that lanthanum ion is seven-coordinated. Six oxygen atoms are from carboxyl groups and cyclic ethers of two DCA ligand, and on oxygen is from a H₂O. The antitumor activities of the complex against HL-60 human leukemia, BGC-823 human gastric carcinoma, Bel-7402 human hepatic carcinoma, Hela human cervical carcinoma were investigated with MTT or SRB assays. Na[La（DCA）₂（H₂O）] exhibits stronger inhibition against certain kinds of cancer cells than Na₂DCA in vitro.更多还原

【关键词】 lanthanum complex； demethylcantharidate group； antitumor activity； rare earths；
【Key words】 lanthanum complex； demethylcantharidate group； antitumor activity； rare earths；

【基金】 ProjectsupportedbytheNationalNaturalScienceFoundationofChina(298902804)

【文献出处】 Journal of Rare Earths ,稀土学报(英文版) , 编辑部邮箱 ,2005年05期

【分类号】R73-3;R914.5;
【被引频次】10
【下载频次】50

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