【摘要】 目的 :探讨内皮素 (ET)与充血性心力衰竭 (CHF)严重程度的关系及卡托普利对其影响。方法 :采用放射免疫法测定ET浓度。6 9例CHF患者为治疗组 (CHF组 ) ,30例正常人为对照组。 6 9例CHF患者中的 12例因有禁忌症而未用卡托普利治疗为非卡托普利组 ,余 5 7例常规口服卡托普利治疗为卡托普利组 ,测入院和治疗 4周时的ET。对随访资料完整的 4 2例卡托普利组患者分别于 8周和 12周时复查ET。结果 :CHF组与对照组比较 ,ET浓度明显增高 (P <0 0 1)。CHF组治疗 4周后ET都有降低 ,但卡托普利组降低明显 (P <0 0 5 )。在 8周与 12周时卡托普利组 4 2例患者ET浓度差异无显著性。结论 :ET参与了CHF的发生发展 ,血浆ET浓度和CHF严重程度呈正相关。血管紧张素转换酶抑制剂 (ACEI)卡托普利应用可降低血浆ET浓度。更多还原

【Abstract】 Objective: To study the relationship of endothelin(ET) level and severity of congestive heart failure(CHF) and the curative effect of captopril. Methods: The plasmatic concentration of ET was detected with radioimmunoassay(RTA) . 69 patients with CHF were selected to experimental group(CHF group) and 30 normal persons to control group. In 69 patients with CHF, 12 cases who did not been treated with Captopril because of contraindication were branded as no- captopril-group, 57 cases treated with captopril as captopril-group. ET level was measured in admission and 4 weeks later. It was measures again in 8 and 12 weeks in 42 cases of follow-up survey in captopril-group. Results: Compared with control group, the plasmatic concentration of ET increased obviously(P<0.01) in CHF group. After 4 weeks, the concentration of ET in captopril-group fell more obviously than that in no- captopril-group. In 42 cases of follow-up survey in captopril-group, the concentration of ET was no difference in 8 and 12 weeks. Conclusions: ET takes part in the generation and development of CHF and has active effect with severity of CHF. ACEI can reduce the plasmatic concentration of ET.更多还原