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多巴胺D₃受体配体的研究和应用

Study and Application of D₃ Receptor Ligand

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【Author】 GU Li-jie 1,2 , CAI Jin 3 , LI Ming-dong 1 , ZHANG Jiao-yue 3 , JI Min 1* (1.Department of Chemistry & Chemical Engineering,Southeast University, Nanjing 210096, China; 2.Department of Pharmaceutical Engineering, Higher Vocational Medical School of Xuzhou, Xuzhou 221116, China; 3. Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China)

【机构】东南大学化学化工系；中国药科大学新药研究中心；东南大学化学化工系江苏南京210096江苏徐州医药高等职业学校制药工程系；江苏徐州221116；江苏南京210009；江苏南京210096；江苏南京210096；

【摘要】综述有潜在治疗价值的多巴胺D3受体配体如多巴胺D3受体激动剂、部分激动剂和多巴胺D3受体拮抗剂的研究和应用近况。多巴胺D3受体与帕金森病、精神分裂症等神经性或精神性疾病及药物成瘾等有关。更多还原

【Abstract】 Some D_ 3 receptor ligands with potential medical value, involving D_ 3 receptor agonists, partial agonists and D_ 3 receptor antagonists were reviewed. D_ 3 receptor is related to many kinds of nervous or psychical disease, such as Parkinsonism and Schizophrenia, and is also related to the drug addiction.更多还原