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环境线索暴露对海洛因戒断者焦虑和抑郁状态及心理渴求的影响

EFFECT OF HEROIN-RELATED CUE ON HEROIN ABSTINENTS IN THE ANXIETY,DEPRESSION AND CRAVING

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【作者】 钟飞吴鎏桢韩济生

【Author】 ZHONG Fei,WU Liuzhen,HAN Jishen (Neuroscience Research Institute Peking University,Beijing,100083)

【机构】 北京大学神经科学研究所北京大学神经科学研究所 北京100083北京100083

【摘要】 目的:研究环境线索对海洛因戒断者心理渴求及焦虑和抑郁症状的影响。方法:选取70例处于戒断60-90d的海洛因依赖者及28例健康志愿者暴露于海洛因相关环境线索中,测量暴露前后视觉模拟尺记录的渴求程度,以及心率、汉密尔顿焦虑和抑郁量表评分,并完成自编海洛因依赖受试者基本情况登记表等社会学资料。采用配对t检验统计暴露前后的渴求程度、心率及焦虑和抑郁评分。结果:暴露后海洛因戒断者的心理渴求和心率明显高于暴露前,差别具有显著性统计学意义(P<0.01)。焦虑和抑郁评分在暴露后明显降低,差异有显著性(P<0.01)。结论:环境线索可以使戒断期海洛因依赖者心理渴求和心率明显增加,但同时可以缓解焦虑和抑郁情绪。

【Abstract】 Objective: To identify the effect of heroin-related cue on the anxiety and depression and craving of heroin abstinents. Methods: Seventy heroin addicts who had finished detoxification and 28 healthy volunteers were enrolled to expose to heroin-related cue.Craving,heart rate,anxiety and depression scores were evaluated by visual analogue scale(VAS),Hamilton anxiety scale(HAMA) and Hamilton rate scale of depression(HRSD).Paired-t test was adopted to compare the difference of VAS,HAMA and HRSD scores before and after exposure. Results: Heroin abstinents’ craving scores and heart rate increased after exposure,and the difference was significant(P<0.01),while their anxiety and depression scores decreased after exposure,and the difference was also significant(P<0.01). Conclusion: Heroin-related cue can induce drug craving of heroin abstinents and alleviate their anxiety and depression symptoms at one time.

【关键词】 环境线索海洛因成瘾者渴求焦虑抑郁
【Key words】 cueheroin addictscravinganxietydepression
【基金】 国家重点基础研究发展计划(973)课题(2003-CB575400);国家自然基金项目(30170814)资助
  • 【文献出处】 中国药物依赖性杂志 ,Chinese Journal of Drug Dependence , 编辑部邮箱 ,2005年06期
  • 【分类号】R749.61
  • 【被引频次】9
  • 【下载频次】173
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