【摘要】 目的观察奥沙利铂联合5-氟尿嘧啶(5-FU)和亚叶酸钙(CF)治疗晚期胃癌临床疗效及其不良反应。方法奥沙利铂100 m g/m 2,静脉滴注2 h,第1天;CF 400 m g/m 2,静脉滴注,第1天;5-FU 400 m g/m 2,静脉推注,第1天;后续5-FU 2600 m g/m 2,静脉持续输注46 h;每2周重复,应用4次奥沙利铂(8周)后判断疗效。结果46例患者中,完全缓解(CR)5例(11%),部分缓解(PR)18例(39%),稳定(SD)16例(35%),进展(PD)7例(15%),CR+PR共23例,近期客观有效率为50%。26例初治患者中,CR 5例,PR10例,SD 8例,PD 3例,有效率58%;20例复治患者中,CR 0例,PR 8例,SD 8例,PD 4例,有效率40%,中位缓解时间为5个月,中位生存期为9个月。主要毒副反应为神经毒性,恶心、呕吐、白细胞和血小板减少程度较轻。结论奥沙利铂联合5-FU/CF治疗晚期胃癌有较好的近期疗效,毒副反应轻而且安全。更多还原

【Abstract】 Objective To evaluate the clinical efficacy and adverse effects of oxaliplatin combined with 5-flu-orouracil(5-FU)/calcium folinate(CF) in the treatment of advanced gastric cancer. Methods Oxaliplatin 100 mg/m2 ivgtt 2hr d1,CF 400 mg/m2 ivgtt d1,5-FU 400 mg/m2 iv bolus d1,5-FU 2600 mg/m2,contimuous intravenous drip(CIV) 46 h,and repeated every 2 weeks.Efficacy was evaluated at 4 cycles (8 weeks). Results Forty-six patients were evaluable for clinical response.Five patients achieved complete response(CR)(11%),18 partial response(PR)(39%),16 stable of disease(SD)(35%),7 progress of disease(PD)(15%),overall response rate(CR+PR) was 50%.Response rates for 1st line and 2nd line patients were 58% and 40%,respectively.Median response time was 5 months and median survival time was 9 months.The main adverse effects were neural toxicity.Nausea/vomiting,leukopenia and thrombocytopenia were mild. Conclusion Oxaliplatin combined with 5-FU/CF is a high response regimen for advanced gastric cancer with mild toxicity,which can be practiced safely.更多还原