【摘要】 目的　观察急性冠脉综合征(ACS)患者部分凝血因子活性水平,探讨其在ACS发病中的意义。方法　测定10 0例急性心肌梗死(AMI)和89例不稳定性心绞痛(UAP)患者急性期凝血因子Ⅴ、Ⅶ、Ⅷ、Ⅸ、Ⅹ、Ⅺ活性(FⅤ:C、FⅦ:C、FⅧ:C、FⅨ:C、FⅩ:C、FⅪ:C) ,并与6 0例稳定性心绞痛(SAP)和6 0例健康对照组进行比较,分析这些因子活性水平与AMI和UAP急性期的关系。结果　AMI和UAP患者急性期FⅤ:C、FⅦ:C、FⅧ:C、FⅨ:C、FⅩ:C、FⅪ:C水平明显高于SAP组和健康对照组,P <0 .0 5 ;SAP组和健康对照组比较无明显差异(P >0 .0 5 )。结论　ACS患者急性期FⅤ:C、FⅦ:C、FⅧ:C、FⅨ:C、FⅩ:C、FⅪ:C水平明显升高,存在高凝状态。更多还原

【Abstract】 Objective To investigate the activity variation of blood coagulation factors and its clinical significance in acute coronary syndrome (ACS). Methods Application of model ACS futura blood coagulation automatic analysis instrument to assay the activity of part of blood coagulation factors in 100 cases of acute myocardial infarction and 89 cases of unstable angina pectoris patients which compared with 60 cases of healthy individuals and 60 cases stable angina pectoris (SAP) patients. Results The patients with acute myocardial infarction and unstable angina pectoris during acute phase had significantly higher plasma FⅤ:C、FⅦ:C、FⅧ:C、FⅨ:C、FⅩ:C、FⅪ:C compared with that of healthy and SAP subjects,patients with SAP had no higher FⅤ:C、FⅦ:C、FⅧ:C、FⅨ:C、FⅩ:C、FⅪ:C compared with that of healthy subjects. Conclusion Significantly higher activation of FⅤ:C、FⅦ:C、FⅧ:C、FⅨ:C、FⅩ:C、FⅪ:C and a hypercoagulant state exist in ACS patients during acute phase by detecting coagulation factors.更多还原