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EFFECTS OF BU GU ZHI(PSORALEA CORYLIFOLIA L) AND BAI ZHI(DAHURIAN ANGELICA ROOT) EXTRACTS ON MELANOCYTE ADHESION AND MIGRATION

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【作者】 马慧群； 冯捷； 张宪旗； 牟宽厚； 刘超； 牛新武； 党倩丽；

【Author】 Ma Huiqun, Feng Jie, Zhang Xianqi, Mu Kuanhou *, Liu Chao, Niu Xinwu, Dang QianliDepartment Of Dermatology, Second Hospital of Xi’an Jiaotong University, Xi’an 710004, China.

【机构】 Department Of Dermatology； Second Hospital of Xi’an Jiaotong University； Xi’an 710004； China； Department of Dermatology； First Hospital of Xi anJiaotong University； Xi an710061 China； China；

【Abstract】 Objective To find direct effect of Chinese herbs Bu Gu Zhi (Psoralea corylifolia L) and Bai Zhi (Dahurian angelica root) Extracts on melanocyte adhesion and migration in vitro. Methods Ethanol extracts obtained from two kind of Chinese medicinable herbs were tested. Human melanocytes were obtained from neonatal foreskins and 48-well culture dish covered with fibronectin were used to perform melanocyte adhesion assay; Motility was assessed using the micropore filter method. Results: The extracts of Bu Gu Zhi(Psoralea corylifolia L), Bai Zhi(Dahurian angelica root) obviously showed an effect in increasing of human melanocyte adhesion and migration on fibronectin. Conclusion It is suggested that Buguzhi(Fructus Psoraleae) and Baizhi(Radix Angelicae Dahuricae) might induce melanocyte adhesion and/or migration in the treatment of vitiligo.

【关键词】 Bu Gu Zhi(Psoralea corylifolia L)； Bai Zhi(Dahurian angelica root)； Melanocyte； Adhesion； Migration； vitiligo；
【Key words】 Bu Gu Zhi(Psoralea corylifolia L)； Bai Zhi(Dahurian angelica root)； Melanocyte； Adhesion； Migration； vitiligo；
【基金】 ThisworkwassupportedbytheNationalNaturalScienceFoudationofChina(No.30200247).
  • 【文献出处】 Academic Journal of Xi’an Jiaotong University ,西安交通大学学报(英文版) , 编辑部邮箱 ,2005年01期
  • 【分类号】R285
  • 【下载频次】37
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